Our genetics research team has recently published a paper on congenital hypothyroidism entitled,” Investigation of the impact of nonsynonymous mutations on thyroid peroxidase dimer”. This paper highlights Thyroid Dyshormonogenesis, hereditary defects in thyroid hormone synthesis and secretion. Thyroid peroxidase dimer protein plays a major role in thyroid hormone synthesis. Nonsynonymous mutations on Thyroid Peroxidase (TPO) gene disrupt binding and interactions of essential ligands with the dimer protein for hormone synthesis. This mechanism of Thyroid Dyshormonogenesis has been explored through computational biology and bioinformatics techniques. Heartfelt Congratulations to our former PhD Fellow Dr. Maliha and the coauthors for their contributions to research.
Link: https://journals.plos.
