Research

BRCA mutation in women with high-grade epithelial Ovarian Cancer

Program Lead Dr. Mohammad Tanbir Habib Communication Mahin Hasan ([email protected]) Abstract BRCA1 and BRCA2 are tumor-suppressing genes, required by the DNA damage-repairing pathway to maintain genomic stability. Malfunctioning of the BRCA1 or BRCA2 gene via hereditary or somatic mutation can cause breast/ovarian cancer. Approximately 15% to 20% of all women with invasive ovarian cancer carry […]

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Thalassemia Awareness and Free Carrier Screening Program

Program Lead Dr. Kasrina Azad Our Approach There are estimated 60,000-70,000 patients are suffering from thalassemia and 2500 thalassemia major cases are added in Bangladesh every year. And, unknowingly and unwittingly they are contributing to the spread of the disease by marrying another carrier. The carriers are otherwise normal individuals Without any signs or symptoms

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Genomic epidemiology and immunodynamics of dengue infection in the context of rapidly escalating mortality rates in Bangladesh

Program Lead Abu Bakar Siddik, Anika Tahsin Our Approach Our approach delves into the multifaceted landscape of dengue fever during an outbreak in Bangladesh. We seek to understand the nuances of the disease’s clinical spectrum by describing the role of dengue serotypes (serotype-specific genotypes) and immunological parameters. To investigate the variables affecting the clinical outcomes

Genomic epidemiology and immunodynamics of dengue infection in the context of rapidly escalating mortality rates in Bangladesh Read More »

Comparative RBD specific IgG antibody response and pulmonary functional activity of the COVID-19 recovered group before and after vaccination

Program Lead Abu Bakar Siddik Our Approach Our COVID-19 research further focused on long-term effects on pulmonary function (PF) as well as serological aspects of individuals recovering from COVID-19 with varying disease severity ranging from mild to severe symptoms. We intend to evaluate their antibody responses, particularly IgG, before and after vaccination. Simultaneously, we examine

Comparative RBD specific IgG antibody response and pulmonary functional activity of the COVID-19 recovered group before and after vaccination Read More »

SARS-CoV-2 circulation detection and serological response among the Forcibly Displaced Myanmar Nationals (FDMNs) in Cox’s Bazar, Bangladesh

Program Lead Abu Bakar Siddik Our Approach As part of our ongoing efforts to contain the COVID-19 pandemic since it first started in 2020, we have extended our research to include the forcibly displaced Myanmar nationals (FDMN)also as known as Rohingya population in Cox’s Bazar, Bangladesh. Recognizing the unique challenges that this vulnerable community faces,

SARS-CoV-2 circulation detection and serological response among the Forcibly Displaced Myanmar Nationals (FDMNs) in Cox’s Bazar, Bangladesh Read More »

Creating Awareness on HPV infection, Vaccination and Cervical Cancer: A road map towards elimination of cervical cancer from Bangladesh

Program Lead Dr. Kasrina Azad Our Approach  This study will be a cross-sectional mixed-method survey through nationwide school-based community awareness programs with a duration of two years (Sep, 2023- Aug, 2025). The target population for the awareness program at the district level will be school girls (aged 10 to 14 years of age), parents, teachers, local

Creating Awareness on HPV infection, Vaccination and Cervical Cancer: A road map towards elimination of cervical cancer from Bangladesh Read More »

Molecular analysis of β-globin and iron metabolizing regulatory genes in thalassemia carriers, HbE/β and β-thalassemia major patients in Bangladesh

Program Lead Rumana Mahtarin Our Approach The research project is investigating the detrimental health effect of thalassemia by molecular analysis of β-globin and iron metabolizing regulatory genes in thalassemia carriers and HbE/β and β-thalassemia major patients in Bangladesh. Association of comorbidities and disruption of iron homeostasis have been explored to disseminate the research findings for

Molecular analysis of β-globin and iron metabolizing regulatory genes in thalassemia carriers, HbE/β and β-thalassemia major patients in Bangladesh Read More »

Antimicrobial Resistance (AMR): The Global Threat

Program Lead  Dr. Zannat Kawser, Sanchita Kar Our Approach Facilitated with conventional microbiology and automated identification and Antimicrobial Sensitivity Testing (AST), ideSHi has been conducting several projects on AMR profiling of WHO priority pathogens. By including advanced high throughput technologies, we are studying AMR at both phenotypic and genotypic perspectives. In our studies, we focus

Antimicrobial Resistance (AMR): The Global Threat Read More »

Respiratory Virus Genomic Surveillance in Bangladesh

Program Lead Dr. Mohammad Tanbir Habib Our Approach To respond to the threat of COVID-19 pandemic, a consortium was initiated in Bangladesh for nationwide SARS-CoV-2 variant surveillance. So far, the consortium has sequenced almost two thousand SARS-CoV-2 genomes, deposited the data in public database (www.gisaid.org) and informed the policymakers about emerging threats. Here, we want

Respiratory Virus Genomic Surveillance in Bangladesh Read More »

A nationwide facility-based study for determination of prevalence of ‘Inborn Errors of Metabolism’ among high-risk neonates and children in Bangladesh.

Inborn Errors of Metabolism (IEM), also known as congenital metabolic disorders or inherited metabolic disorders, are a group of rare genetic disorders that affect the body’s ability to carry out essential chemical reactions required for normal growth, development, and overall functioning. These disorders are typically caused by mutations in genes that encode enzymes or other

A nationwide facility-based study for determination of prevalence of ‘Inborn Errors of Metabolism’ among high-risk neonates and children in Bangladesh. Read More »

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